Patent · US Active

Phagocytic cell delivery of RNAI

US8815818B2 · kind B2 · utility

52Cited by

197References

17Claims

0Family size

Assignee

RXi Pharmaceuticals Corporation · US

Inventors

Dmitry Samarsky · Berlin, DE
Tod M. Woolf · Sudbury, US

Key dates

Filing date	Jul 17, 2009
Grant date	Aug 26, 2014
Priority date	—
Expiry date	Aug 16, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/32
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides a particulate delivery system for delivering an RNAi construct to phagocytic cells such as macrophages, comprising various configurations of a complex comprising a phagocytic cell-targeting moiety and an RNAi construct. The invention further provides methods of making the delivery system, and their uses, such as treating phagocytic cell-associated disease conditions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.