Heterocyclic amides as rock inhibitors

US8815873B2 · kind B2 · utility

Assignee

• Amakem NV · BE

Inventors

• Dirk Leysen · Diepenbeek, BE
• Olivier Defert · Diepenbeek, BE
• Nadzeya Kaval · Diepenbeek, BE
• Petra Blom · Laarne, BE
• Sandro Boland · Diepenbeek, BE

Key dates

• Filing date: Mar 4, 2011
• Grant date: Aug 26, 2014
• Expiry date: Mar 4, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.