Methods and compositions for modulating IRE1, SRC, and ABL activity

US8815885B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Peter Walter · San Francisco, US
• Alexei Korennykh · Princeton, US
• Kevan M. Shokat · San Francisco, US
• Chao Zhang · 安丰镇, CN
• Janet Finer-Moore · San Bruno, US
• Robert M. Stroud · San Francisco, US
• Pascal Egea · San Francisco, US
• Andrei Korostelev · Santa Cruz, US
• Arvin Dar · San Francisco, US
• Sebastian Bernales · Piedmont, US

Key dates

• Filing date: Sep 15, 2009
• Grant date: Aug 26, 2014
• Expiry date: Mar 1, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/4155
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.