Metal-catalyzed copolymerization of imines and carbon monoxide as a route to synthesize polypeptides

US8815913B2 · kind B2 · utility

Assignee

• Nankai University · CN

Inventors

• Huailin Sun · Tianjin, CN
• Jian Zhang · Taizhou City, CN
• Qiuhua Liu · Houston, US
• Lei Yu · Huangguan, CN
• Jiangyu Zhao · Tianjin, CN

Key dates

• Filing date: Jun 8, 2009
• Grant date: Aug 26, 2014
• Expiry date: Feb 10, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K1/02
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Polypeptides of formula (I):wherein R1 and R2 are substituents independently selected from substituted and un-substituted alkyl groups and substituted and un-substituted aryl groups, and n is an integer greater than or equal to 2. Synthesis methods are also provided that do not use amino acids as starting materials, but instead employ imines and carbon monoxide as monomers that undergo transition metal-catalyzed alternating copolymerization to directly provide polypeptides using an acylcobalt catalyst with the following structural formula:wherein R is selected from the group consisting of alkyl, phenyl, and substituted phenyl groups.