Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease

US8815942B2 · kind B2 · utility

Assignee

• The Royal Institution for the Advancement of Learning/McGill University · CA

Inventors

• Philippe Gros · Salaberry-de-Valleyfield, CA
• Gundula Min-Oo · San Francisco, US
• Anny Fortin · Montréal, CA

Key dates

• Filing date: Oct 20, 2011
• Grant date: Aug 26, 2014
• Expiry date: Sep 25, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds, methods, uses, compositions, combinations, kits and packages for the prevention and/or treatment of parasite infection (e.g., Plasmodium parasites) and/or disease (e.g., malaria) based on uses of (a) cystamine, cysteamine, and analogs, derivatives, prodrugs, precursors thereof; an agent capable of inducing their production; and/or salts thereof, and (b) artemisinin and functional derivative, analog, conjugate, metabolite, prodrug or precursor thereof, and/or salts thereof.