Inhibition of proliferation and fibrotic response of activated corneal stromal cells
US8815946B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Jan 26, 2009 |
| Grant date | Aug 26, 2014 |
| Priority date | — |
| Expiry date | Jan 27, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P27/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are methods of preventing a fibrotic response and/or scarring in a wound, comprising administering to a subject a composition comprising an amount of an amide or ester of an alpha-ketoalkanoic acid effective to inhibit a proliferative and/or fibrotic response in the wound. In one instance, the wound is to a subject's cornea, such as a wound resulting from refractive surgery. In one embodiment, the amide or ester of an alpha-ketoalkanoic acid is ethyl pyruvate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.