Process for the preparation of dronedarone
US8816103B2 · kind B2 · utility
13Cited by
3References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 14, 2013 |
| Grant date | Aug 26, 2014 |
| Priority date | — |
| Expiry date | Jan 14, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/82
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject of the invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-di-n-butylamino)-propoxy]benzoyl}benzofuran-5-yl]-methanesulfonamide of formula I:and pharmaceutically acceptable salts thereof wherein the acyl group of the benzofuran derivative of the general formula II:where R represents C1-4 alkyl-, C1-4 alkoxy- or aryl group, is selectively cleaved and if desired, the resulting compound of formula I is transformed into its salt.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.