Highly compressible, low density ground calcium carbonate granulation and a related method of preparation
US8821942B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 5, 2012 |
| Grant date | Sep 2, 2014 |
| Priority date | — |
| Expiry date | May 27, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K33/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A calcium carbonate granulation and a method for preparing a calcium carbonate granulation are provided. The method includes applying an atomized binder to powdered calcium carbonate in a fluid bed granulator at a relatively high atomization pressure to achieve a reduced binder droplet size, and drying the resulting composition at elevated temperatures in a fluidized bed dryer. The resulting granulation include porous granules having a lower density and reduced mean particle size with improved compressibility. In addition, the resulting granulation can be compacted into tablets having a hardness 50% greater than the hardness of tablets formed from commercially available granulations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.