Method for differentiating spitz nevi from spitzoid malignant melanoma
US8822159B2 · kind B2 · utility
2Cited by
1References
20Claims
0Family size
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Key dates
| Filing date | Feb 1, 2013 |
| Grant date | Sep 2, 2014 |
| Priority date | — |
| Expiry date | Feb 1, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5743
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides for a mass spectrometry proteomic approach to distinguishing Spitz nevi from Spitzoid malignant melanoma. Histology directed mass spectral profiling allows for targeted analysis of sites of melanocytic lesion within formalin-fixed, paraffin embedded excisional biopsies. The classification system identified 5 peptide peaks, of which two have been identified as originating from vimentin and actin. A sensitivity and specificity for Spitz nevi of 97% and 90%, respectively, were achieved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.