Method of detecting isolevuglandin phospholipid adducts
US8822172B2 · kind B2 · utility
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24Claims
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Key dates
| Filing date | Jan 25, 2010 |
| Grant date | Sep 2, 2014 |
| Priority date | — |
| Expiry date | May 20, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6848
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of measuring isolevuglandin and/or levuglandin adducts associated with oxidative injury in a subject includes obtaining a bodily sample from a subject suspected of including isolevuglandin and/or levuglandin phospholipid adducts, hydrolyzing isolevuglandin and/or levuglandin phospholipid adducts from the sample with an enzyme that forms isolevuglandin and/or levuglandin phospholipid derivatives, and determining the amount of isolevuglandin and/or levuglandin phospholipid derivatives by mass spectrometry.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.