N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors

US8822464B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Matthias Grauert · Ingelheim am Rhein, DE
• Daniel Bischoff · Grand Rapids, US
• Georg Dahmann · Biberach an der Riß, DE
• Raimund Kuelzer · Mittelbiberach, DE
• Klaus Rudolf · Warthausen, DE

Key dates

• Filing date: Nov 26, 2012
• Grant date: Sep 2, 2014
• Expiry date: Dec 20, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of formula Itheir use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.