Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments

US8822495B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Lothar Schwink · Stadtallendorf, DE
• Siegfried Stengelin · Frankfurt am Main, DE
• Matthias Gossel · Frankfurt am Main, DE
• Gerhard Hessler · Hofheim, DE
• Torsten Haack · Frankfurt am Main, DE
• Petra Lennig · Mainz, DE

Key dates

• Filing date: Aug 14, 2008
• Grant date: Sep 2, 2014
• Expiry date: Dec 22, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to azacyclyl-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the azacyclyl-substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.