Dual-acting pyrazole antihypertensive agents
US8822522B2 · kind B2 · utility
0Cited by
30References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 26, 2012 |
| Grant date | Sep 2, 2014 |
| Priority date | — |
| Expiry date | Dec 29, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In one aspect, the invention relates to compounds having the formula:wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.