Use of targeted nitroxide agents in mitigating or treating radiation injury

US8822541B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Peter Wipf · Pittsburgh, US
• Natalia A. Belikova · Downers Grove, US
• Jianfei Jiang · Pittsburgh, US
• Joshua G. Pierce · Raleigh, US
• Joel S. Greenberger · Dorpsstraat, US
• Michael W. Epperly · Pittsburgh, US
• Valerian Kagan · Pittsburgh, US

Key dates

• Filing date: Jan 14, 2011
• Grant date: Sep 2, 2014
• Expiry date: Dec 2, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.