Dimeric fusion proteins and related compositions and methods

US8822642B2 · kind B2 · utility

Assignee

• ZYMOGENETICS INC. · US

Inventors

• Steven D. Levin · Seattle, US
• Margaret D. Moore · Seattle, US
• Craig Ostrander · Bothell, US
• Katherine E. Lewis · Lake Forest Park, US
• David Taft · Kirkland, US
• Robert J. Rosler · Lynnwood, US
• Anitra Wolf · Puyallup, US
• Megan M. Lantry · Redmond, US

Key dates

• Filing date: Jun 7, 2011
• Grant date: Sep 2, 2014
• Expiry date: Jun 7, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods relating to soluble dimeric proteins are disclosed. The dimeric proteins comprise first and second polypeptide fusions linked via a dimerizing domain, each polypeptide fusion comprising first and second monomer domains corresponding to a cytokine or an extracellular domain of a cell-surface receptor. The monomer domains may be positioned amino terminal and carboxyl terminal to the dimerizing domain. Alternatively, the monomer domains may be positioned in tandem, either carboxyl terminal or amino terminal to the dimerizing domain. The dimeric proteins are useful in methods for therapy, diagnosis, and research.