Patent · US Active

2'-O-modified RNA

US8822671B2 · kind B2 · utility

36Cited by

0References

10Claims

0Family size

Assignees

THE UNIVERSITY OF TOKYO · JP
Chiralgen, Ltd. · JP

Inventors

Mamoru Shimizu · Uruma, JP
Takeshi Wada · Minamisoma, JP
Kouichiro Arai · Tokyo, JP

Key dates

Filing date	Nov 28, 2011
Grant date	Sep 2, 2014
Priority date	—
Expiry date	Nov 28, 2031

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A 2′-modified ribonucleoside having an alkoxymethyl protective group can be imparted with a high duplex-forming ability by introducing, as a substituent, a halogen atom into the protective group moiety. A modified form of RNA having a halogen-substituted alkoxymethyl protective group exhibits a high duplex-forming ability that is comparable to the duplex-forming ability of a 2′-O-methyl modified nucleic acid.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.