Low-substituted hydroxypropylcellulose and solid preparation comprising the same
US8822675B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 8, 2011 |
| Grant date | Sep 2, 2014 |
| Priority date | — |
| Expiry date | Dec 27, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2054
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is nonionic and excellently stable low-substituted hydroxypropylcellulose having improved compressibility and flowability, and further having improved disintegration and texture in oral cavity. More specifically provided is low-substituted hydroxypropylcellulose having a crystallinity of 60% or less, a degree of hydroxypropoxyl substitution of 5 to 9% by weight, and an aspect ratio of less than 2.5, wherein the crystallinity is calculated based on a diffraction intensity by wide-angle X-ray diffraction measurement according to the following formula (1):Crystallinity(%)={(Ic−Ia)/Ic}×100 (1)wherein Ic means a diffraction intensity at a diffraction angle 2θ of 22.5° and Ia means a diffraction intensity at a diffraction angle 2θ of 18.5°.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.