Patent · US Active

Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof

US8828385B2 · kind B2 · utility

8Cited by

29References

8Claims

0Family size

Assignee

Fibron Limited · IL

Inventors

Avner Yayon · Afula, IL
Eran Rom · Rehovot, IL
Elisabeth Thomassen-Wolf · Birkenfeld, DE
Eric Borges · Weitensfeld im Gurktal, AT

Key dates

Filing date	Feb 27, 2009
Grant date	Sep 9, 2014
Priority date	—
Expiry date	Feb 24, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Molecules comprising the antigen-binding portion of antibodies that block constitutive and/or ligand-dependent activation of a receptor protein tyrosine kinase, such as fibroblast growth factor receptor 3 (FGFR3), are found through screening methods, where a soluble dimeric form of a receptor protein tyrosine kinase is used as target for screening a library of antibody fragments displayed on the surface of bacteriophage. The molecules of the present invention which block constitutive activation can be administered to treat or inhibit skeletal dysplasia, craniosynostosis disorders, cell proliferative diseases or disorders, or tumor progression associated with the constitutive activation of a receptor protein tyrosine kinase.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.