Markers for determination of patient responsiveness

US8828668B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Robert C. Axtell · Menlo Park, US
• Lawrence Steinman · Stanford, US
• May Han · Brookline, US
• Brigit A. de Jong · Nijmegen, NL
• Chander Raman · Birmingham, US
• Michael Walker · Austin, US
• Jing Shi · Carlsbad, US

Key dates

• Filing date: Feb 11, 2011
• Grant date: Sep 9, 2014
• Expiry date: Mar 23, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A90/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods are provided for prognostic classification of inflammatory diseases, e.g. inflammatory demyelinating disease, patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Assessment of this signature pattern thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is multiple sclerosis or neuromyelitis optica.