Patent · US Active

Genetically modified host cells and use of same for producing isoprenoid compounds

US8828684B2 · kind B2 · utility

4Cited by

9References

22Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Jay D. Keasling · Berkeley, US
James Kirby · Berkeley, US
Eric M. Paradise · Vienna, US

Key dates

Filing date	Jul 21, 2005
Grant date	Sep 9, 2014
Priority date	—
Expiry date	Oct 11, 2028

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.