Patent · US Active

Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity

US8828937B2 · kind B2 · utility

2Cited by

10References

23Claims

0Family size

Assignee

Haase Investments UG · DE

Inventors

Petra Seemann · Berlin, DE
Stefan Mundlos · Berlin, DE
Carsten Reissner · Munster, DE
Georg Duda · Berlin, DE
Julia Zimmer · Berlin, DE

Key dates

Filing date	Mar 11, 2010
Grant date	Sep 9, 2014
Priority date	—
Expiry date	Apr 11, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.