Gold(III) complexes containing N-heterocyclic carbene ligand, synthesis, and their applications in cancer treatment and thiol detection

US8828984B2 · kind B2 · utility

Assignee

• University of Hong Kong · CN

Inventors

• Chi-Ming Che · Hong Kong, CN
• Taotao Zou · Hong Kong, CN

Key dates

• Filing date: Nov 13, 2013
• Grant date: Sep 9, 2014
• Expiry date: Nov 13, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/582
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein is a method of synthesis of Au(III)-NHC complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Au(III)-NHC complexes. Also provided is method of detecting thiol in a biological system. The Au(III)-NHC complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growth in vivo.