Pyrimidine compounds and their uses

US8828999B2 · kind B2 · utility

Assignee

• ORCHID CHEMICALS & PHARMACEUTICALS LIMITED · IN

Inventors

• Ganapavarapu Veera Raghava Sharma · Visakhapatnam, IN
• Venkatesan Parameswaran · Chennai, IN
• Gopalan Balasubramanian · Chennai, IN
• Santosh Vishwakarma · Darsi, IN
• Sanjeev Saxena · Chennai, IN

Key dates

• Filing date: Feb 26, 2013
• Grant date: Sep 9, 2014
• Expiry date: Feb 26, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D265/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyrimidine compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof, are useful are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases and in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever.