System and methods for determining molecules using mass spectrometry and related techniques
US8829432B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Mar 21, 2013 |
| Grant date | Sep 9, 2014 |
| Priority date | — |
| Expiry date | Mar 21, 2033 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01J49/0409
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention generally relates to mass spectrometry and related techniques, and in some cases, to determining single species using mass spectrometry. In certain instances, polymers such as DNA or RNA can also be sequenced. Certain embodiments of the invention relate to passing a polymer, such as DNA, RNA, a protein, a polypeptide, a polysaccharide, etc., through a pore and cleaving the polymer in sequence. For instance, the polymer may be cleaved using a laser or an electric field. In some embodiments, a property of at least one subunit of a polymer is determined using mass spectrometry. In some embodiments, a single ion (which may be a subunit of a polymer, or an ion based on another species) can be isolated in a mass spectrometer and a signal generated from the single ion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.