Medical implants and methods of making medical implants
US8834913B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 28, 2009 |
| Grant date | Sep 16, 2014 |
| Priority date | — |
| Expiry date | Aug 10, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2400/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.