Methods of incorporating amino acid analogs into proteins
US8835162B2 · kind B2 · utility
12Cited by
7References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 28, 2012 |
| Grant date | Sep 16, 2014 |
| Priority date | — |
| Expiry date | Dec 28, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.