Cyclic angiotensin analogs
US8835375B2 · kind B2 · utility
3Cited by
2References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 7, 2007 |
| Grant date | Sep 16, 2014 |
| Priority date | — |
| Expiry date | Apr 11, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/25
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The invention relates to analogs of angiotensins, in particular to cyclised analogs having Ang(1-8) agonistic or antagonistic activity and to cyclised Ang(1-7) analogs with agonistic or antagonistic activity and displaying improved proteolytic resistance compared to their linear counterparts. Provided is a cyclic angiotensin peptide analog comprising a thioether-bridge linkage between the amino acids corresponding to positions Tyr4 and Pro7 in naturally occurring Angiotensin. Also provided is the use of analogs in therapy, for example hypertension.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.