Mimetic peptides and the use thereof in the form of 20S, 26S and immunoproteasome inhibitors

US8835392B2 · kind B2 · utility

Assignees

• Technische Universität Wien · AT
• CHARITÉ—UNIVERSITÄTSMEDIZIN BERLIN · DE

Inventors

• Boris Schmidt · Darmstadt, DE
• Sumaira Umbreen · Darmstadt, DE
• Hannes Braun · Hofheim, DE
• Peter-Michael Kloetzel · Berlin, DE
• Ulrike Kuckelkorn · Berlin, DE

Key dates

• Filing date: Mar 3, 2006
• Grant date: Sep 16, 2014
• Expiry date: Nov 28, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to peptide-mimetic compounds, the synthesis and use thereof fort he inhibition of proteasomes and the induction of apoptosis in tumor cells. The present invention furthermore relates to pharmaceutical compositions comprising the compounds and the use of the compounds for a treatment of diseases, in particular cancer and neurodegenerative diseases.