Algin oligosaccharides and the derivatives thereof as well as the manufacture and the use of the same
US8835403B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Feb 25, 2005 |
| Grant date | Sep 16, 2014 |
| Priority date | — |
| Expiry date | Nov 14, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0084
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of β-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The present invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedures that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2-6 and the temperature of 100-120° C., and pH is adjusted to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative degradation product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.