Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8835426B2 · kind B2 · utility
1Cited by
47References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 26, 2008 |
| Grant date | Sep 16, 2014 |
| Priority date | — |
| Expiry date | Jul 2, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to novel compounds of the Formula (I),pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds of the Formula (I) and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.