Synthesis of novel antimicrobials
US8835476B2 · kind B2 · utility
1Cited by
7References
10Claims
0Family size
Inventors
Key dates
| Filing date | Mar 6, 2006 |
| Grant date | Sep 16, 2014 |
| Priority date | — |
| Expiry date | Feb 22, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and P1, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.