Patent · US Active

Methods to increase the photostability of dyes

US8835632B2 · kind B2 · utility

0Cited by

1References

3Claims

0Family size

Assignee

The University of North Carolina at Chapel Hill · US

Inventors

Klaus Hahn · Chapel Hill, US
Alexei Toutchkine · Chapel Hill, US

Key dates

Filing date	Jun 20, 2008
Grant date	Sep 16, 2014
Priority date	—
Expiry date	Apr 19, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC09B23/107
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The presently disclosed subject matter provides dyes having an improved photostability, biosensors comprising such dyes, and methods of use thereof, including methods for detecting target molecules in a sample under test and for live-cell imaging. The dyes can include a binding member, including a biomolecule or fragments thereof, which can interact with target molecules of interest and can be specific to a given conformational state or covalent modification, e.g., phosphorylation, of the target molecule. The presently disclosed dyes can be used for detecting changes in the binding, conformational change, or posttranslational modification of the target molecule.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.