Process for preparing olopatadine and/or a pharmaceutically acceptable salt thereof
US8835655B2 · kind B2 · utility
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3References
16Claims
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Key dates
| Filing date | Feb 1, 2010 |
| Grant date | Sep 16, 2014 |
| Priority date | — |
| Expiry date | Feb 13, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.