Process for the preparation of intermediates for the manufacture of NEP inhibitors

US8835668B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• David Hook · Rheinfelden, CH
• Jianguang Zhou · 林湖乡, CN
• Yunzhong Li · 安丰镇, CN

Key dates

• Filing date: Aug 22, 2011
• Grant date: Sep 16, 2014
• Expiry date: Sep 8, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.