Genetically modified organism for the production of lipids

US8841114B2 · kind B2 · utility

Assignee

• ORGANOBALANCE GMBH · DE

Inventors

• Christine Lang · Berlin, DE
• Andreas Raab · Neuler, DE

Key dates

• Filing date: Aug 4, 2010
• Grant date: Sep 23, 2014
• Expiry date: Aug 4, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA: sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.