Use of inhibitors of Zdhhc2 activity for modulation of adipogenesis
US8841270B2 · kind B2 · utility
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9Claims
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Inventors
Key dates
| Filing date | May 19, 2010 |
| Grant date | Sep 23, 2014 |
| Priority date | — |
| Expiry date | Sep 23, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/91051
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns Zdhhc2, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Zdhhc2 activity in adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Zdhhc2 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.