Antimicrobials

US8841306B2 · kind B2 · utility

Assignee

• PANACEA BIOTEC LIMITED · IN

Inventors

• Rajesh Jain · New Delhi, IN
• Sanjay Trehan · Hyderabad, IN
• Jagattaran Das · New Delhi, IN
• Sandeep Kanwar · New Delhi, IN
• Sitaram Kumar Magadi · Hyderabad, IN
• Sudhir Kumar Sharma · New Delhi, IN

Key dates

• Filing date: Nov 18, 2009
• Grant date: Sep 23, 2014
• Expiry date: Dec 16, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel phenyl oxazolidinone compounds of formula I, their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula I or their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of formula I and methods of using them. The compounds of the present invention are useful as antimicrobial agents, effective against a number of aerobic and/or anaerobic Gram positive and/or Gram negative pathogens such as multi drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioides, Clostridia, H. influenza, Moraxella, acid-fast organisms such as Mycobacterium tuberculosis as well as Linezolid resistant species of Staphylococcus and Enterococcus.