Quinoline derivatives as antibacterial agents

US8841321B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Koenraad Jozef Lodewijk Marcel Andries · Beerse, BE
• Anil Koul · Edegem, BE
• Jérôme Emile Georges Guillemont · Andé, FR
• David Francis Alain Lançois · Louviers, FR
• Magali Madeleine Simone Motte · Louviers, FR
• Ismet Dorange · Nacka, SE
• Leo Jacobus Jozef Backx · Arendonk, BE
• Lieven Meerpoel · Beerse, BE

Key dates

• Filing date: Jun 26, 2006
• Grant date: Sep 23, 2014
• Expiry date: Nov 14, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/227
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula; R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; R4 and R5 are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a ring; R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkythioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R6 radicals may be taken together to form a bivalent radical of formula —CH═CH—CH═CH—; r is 1, 2, 3, 4 or 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo; or R8 …