Process for cyclooxygenase-2 selective inhibitor

US8841457B2 · kind B2 · utility

Assignee

• Virdev Intermediates Pvt. Ltd. · IN

Inventors

• Dharmesh Shah · Manesar, IN
• Sanjay Amratlal Solanki · Egham, GB
• Viral Narendra Jariwala · Amroli, IN
• Ashok Vasantray Vyas · Vadodara, IN
• Ashokkumar Bhikhubhai Mistry · Navsari, IN

Key dates

• Filing date: Nov 15, 2011
• Grant date: Sep 23, 2014
• Expiry date: Nov 15, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/50
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention describes a process for preparing a cyclooxygenase-2 selective inhibitor. It provides a synthetic procedure for the said substance namely 5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine of formula (I). The invention also relates to preparation of a new intermediate of formula (IV) and a process to prepare it. Furthermore, the invention describes a process for preparing another key intermediate of formula (II). Compounds of formula (IV) and formula (II) are useful intermediates in synthesis of the said cyclooxygenase-2 inhibitor.