Assays

US8846313B2 · kind B2 · utility

Assignee

• CLONDIAG GMBH · DE

Inventors

• Katrin Steinmetzer · Jena, DE
• Eugen Ermantraut · Jena, DE
• Torsten Schulz · Pinneberg, DE
• Thomas Kaiser · Hohlstedt, DE
• Thomas Ullrich · Jena, DE

Key dates

• Filing date: Nov 6, 2007
• Grant date: Sep 30, 2014
• Expiry date: Apr 2, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative of the presence and/or amount of the target molecules, a micro fluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the micro fluidic network.