Targeted gene modification by parvoviral vectors
US8846387B2 · kind B2 · utility
16Cited by
18References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 24, 2011 |
| Grant date | Sep 30, 2014 |
| Priority date | — |
| Expiry date | May 24, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic modification to a preselected target locus in a cellular genome by homologous pairing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.