4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators

US8846655B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Steven J. Coats · McDonough, US
• Haiyan Bian · Princeton, US
• Chaozhong Cai · North Wales, US
• Bart DeCorte · Raritan, US
• Li Liu · Doylestown, US
• Mark J. Macielag · Spring House, US
• Scott L. Dax · Landenberg, US
• Philip Pitis · Valley Forge, US
• Peter J. Connolly · New Providence, US
• Wei He · Audubon, US

Key dates

• Filing date: Oct 28, 2010
• Grant date: Sep 30, 2014
• Expiry date: Aug 19, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D453/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:wherein R1, R2, R3, Ra, and Y are defined herein.