Heterocyclic alkynyl benzene compounds and medical compositions and uses thereof

US8846671B2 · kind B2 · utility

Assignee

• Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences · CN

Inventors

• Ke Ding · 流花街道, CN
• Deping Wang · Furlong, US
• Duanqing Pei · Tangxia, CN
• Zhang Julia Zhang · Scotch Plains, US
• Mengjie Shen · Tangxia, CN
• Kun Luo · Hsinchu, TW
• Yubing Feng · Tangxia, CN

Key dates

• Filing date: Jun 3, 2011
• Grant date: Sep 30, 2014
• Expiry date: Jun 6, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The heterocyclic alkynyl benzene compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in preparing drugs for preventing or treating tumors. The compounds can overcome the clinically induced resistance against Gleevec.