Heterocyclic carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring

US8846690B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Dieter Kadereit · Kelkheim, DE
• Matthias Schaefer · Frankfurt am Main, DE
• Stephanie Hachtel · Frankfurt am Main, DE
• Axel Dietrich · Frankfurt am Main, DE
• Thomas Huebschle · Frankfurt am Main, DE
• Katrin Hiss · Frankfurt am Main, DE

Key dates

• Filing date: Jan 12, 2011
• Grant date: Sep 30, 2014
• Expiry date: Sep 11, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Heterocyclic carboxylic acid derivatives comprising a 2,5-substituted oxazolopyrimidine ring as Edg-1 receptor agonistsThe present invention relates to oxazolopyrimidine compounds of the formula I,in which A, R1, R2, R3, X and Y are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.