Patent · US Active

6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

US8846712B2 · kind B2 · utility

1Cited by

0References

7Claims

0Family size

Assignee

Sanofi · FR

Inventors

Matthias Loehn · Frankfurt am Main, DE
Maria MENDEZ-PEREZ · Frankfurt am Main, DE
Stefania PFEIFFER-MAREK · Frankfurt, DE
Aimo Kannt · Dreieich, DE
Guillaume BEGIS · Paris, FR
Olivier Duclos · Paris, FR
Federic Jeannot · Paris, FR

Key dates

Filing date	Sep 12, 2011
Grant date	Sep 30, 2014
Priority date	—
Expiry date	Feb 5, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D487/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula I,in which R1, R2, R3, R4 and R5 are defined as indicated below. The compounds of the formula I are kinase inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula I, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.