Compounds and methods for altering lifespan of eukaryotic organisms

US8846747B2 · kind B2 · utility

Assignees

• University of Rochester · US
• Southern Research Institute · US

Inventors

• David Goldfarb · Victor, US
• Joseph A. Maddry · Birmingham, US
• Lynn Rasmussen · Odenville, US
• Ellie Lucille White · Birmingham, US
• Krister Wennerberg · Kristiansund, NO

Key dates

• Filing date: Nov 17, 2010
• Grant date: Sep 30, 2014
• Expiry date: Jan 6, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation.