Oligonucleotide with protected base
US8846885B2 · kind B2 · utility
21Cited by
1References
22Claims
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Key dates
| Filing date | Feb 15, 2013 |
| Grant date | Sep 30, 2014 |
| Priority date | — |
| Expiry date | Feb 15, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/173
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method.It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3′-position.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.