Double-stranded RNA molecules with stability in mammalian body fluid, preparation and application thereof
US8846895B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Mar 29, 2011 |
| Grant date | Sep 30, 2014 |
| Priority date | — |
| Expiry date | Mar 29, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention discloses preparation and application of double-stranded RNA molecules stable in mammalian body fluids. The mammalian-body-fluid-stable RNA molecules disclosed in the present invention are comprised of only unmodified nucleotides. For the first time, the present invention discloses the applications of mammalian-body-fluid-stable RNA molecules for immunotherapy and siRNA drug development.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.