Process of isolating enantiomer components from enantiomer mixtures by particle-size-controlled crystallization

US8846911B2 · kind B2 · utility

Assignee

• POXEL · FR

Inventors

• David Maillard · Coventry, GB
• Guntram Koller · Groß-Umstadt, DE
• Ewgenij Wakaresko · Reichelsheim, DE
• Sabine Gottburg-Reininger · Darmstadt, DE

Key dates

• Filing date: Aug 26, 2013
• Grant date: Sep 30, 2014
• Expiry date: Aug 26, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention discloses a process for isolating enantiomer components from a mixture of enantiomers through particle-size-controlled crystallization, comprising the steps of: (a) forming a solution of a mixture of enantiomers (R) and (S) in a solvent in the absence of any further additives or agents; (b) seeding the solution of step (a) simultaneously or consecutively with seed crystals of enantiomer (R) and with seed crystals of enantiomer (S), wherein the seed crystals of enantiomer (R) differ in size and/or in quantity from the seed crystals of enantiomer (S) to allow separation of the crystals composed of a mixture enriched with enantiomer (R) from the crystals composed of a mixture enriched with enantiomer (S); (c) inducing simultaneous crystallization of enantiomer (R) and enantiomer (S); and (d) isolating crystals composed of a mixture enriched with enantiomer (R) from crystals composed of a mixture enriched with enantiomer (S) through size separation of the crystals, preferably through sieving, melting or sedimentation, in particular through sieving.