Patent · US Active

Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists

US8846945B2 · kind B2 · utility

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3Claims

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Inventors

Michael Patrick Dillon · Mill Valley, US
Ronald Charles Hawley · Oakland, US
Li Chen · Sha Tin, CN
Lichun Feng · Shanghai, CN
Minmin Yang · Nanjing, CN

Key dates

Filing date	May 2, 2012
Grant date	Sep 30, 2014
Priority date	—
Expiry date	May 2, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D498/08
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compounds of the formula I:or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5 and R6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.